Azathioprine induced serious portal hypertension : a case series of three IBD patients and review of the literature
| Journal | Volume 76 - 2013 |
| Issue | Fasc.3 - Original articles |
| Author(s) | D. Dooremont, J. Decaestecker, D. De Wulf, G. Ghillebert, H. Van Vlierberghe, J. Van Dorpe, F. Baert |
| Full article |
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| (1) Dept of Gastroenterology at H.-Hart ziekenhuis Roeselare- Menen VZW, Roeselare, Belgium ; (2) Dept of Gastroenterology & Hepatology, Ghent University Hospital, Gent, Belgium ; (3) Dept of Anatomopathology at H.-Hart ziekenhuis Roeselare-Menen VZW, Roeselare, Belgium. |
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We report 3 male IBD patients (2 Crohn's Disease, 1 Ulcerative Colitis) developing thrombocytopenia and splenomegaly on aza- thioprine treatment. All patients were diagnosed with significant portal hypertension due to histological proven nodular regenera- tive hyperplasia (NRH) of the liver. In two of three patients, liver function tests remained completely normal. In addition we provide a short literature review of azathioprine induced NRH covering etiology, imaging, pathology, prognosis and treatment. (Acta gastroenterol. belg., 2013, 76, 342-346). |
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© Acta Gastro-Enterologica Belgica. PMID 24261031 |
