First long-term prospective case series of Percutaneous Endoscopic Gastrostomy with Jejunal Extension for drug administration

Direct jejunal feeding by Percutaneous Endoscopic Gastrostomy with Jejunal Extension (PEG-J) or direct percutaneous endoscopic jejunostomy (DPEJ) is more indicated than gastric feeding in patients with aspiration of gastric contents, gastroparesis or gastric outlet obstruction. Other indication is administration of drugs that must be directly delivered to duodenum or jejunum to achieve a precise and controlled absorption. In this setting, PEG-J may be preferable to DPEJ, despite the risk of tube dysfunction or dislocation (1, 2). There are large series describing DPEJ outcomes (3), but the long- term outcome of PEG-J is not well reported, particularly regarding drug administration.