Regression of gastric de novo diffuse large B-cell lymphoma following Helicobacter pylori eradication: a case report
| Journal | Volume 79 - 2016 |
| Issue | Fasc.3 - Case reports |
| Author(s) | Makoto Saito, Manabu Masutani, Katsuhiro Mabe, Koh Izumiyama, Akio Mori, Tatsuro Irie, Masanori Tanaka, Masanobu Morioka, Mishie Tanino |
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| (1) Department of Internal Medicine and Hematology, Aiiku Hospital, Japan., (2) Department of Internal Medicine, Owl Medical Clinic, Japan., (3) Division of Endoscopy, Hokkaido University Hospital, Japan. (4) Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Japan. |
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We report a case of primary gastric diffuse large B-cell lymphoma (DLBCL), de novo DLBCL without the features of mucosa- associated lymphoid tissue (MALT) lymphoma, which regressed after Helicobacter pylori (HP) eradication. A 27-year-old Japanese female with epigastralgia was revealed to have ulcerated lesions in the angle and antral regions on gastroscopy. Biopsy specimen was consistent with a diagnosis of DLBCL without MALT lymphoma component, indicating de novo development. Her clinical staging on the Lugano system was Stage I. HP was positive on a rapid urease test, and she received HP eradication therapy twice, because the first therapy was not successful. On gastroscopy performed 1 month after the second HP eradication therapy, no ulcerated lesion was noted, and the lymphoma cells had regressed histopathologically. (Acta gastroenterol. belg., 2016, 79, 367-369). |
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© Acta Gastro-Enterologica Belgica. PMID 27821034 |
