Evaluation of oxidant - anti-oxidants status in patients with mild acute pancreatitis

Background and aim : Acute pancreatitis (AP), an inflammatory disorder of the pancreas, is associated with significant morbidity and mortality. The pathogenesis of AP has been suggested to involve high oxidative stress (OS), combined with inadequate anti- oxidant status. We aimed to investigate the levels of serum total anti-oxidant status (TAS), total oxidant status (TOS) and ischemia-modified al- bumin (IMA) in patients with mild AP. Methods : Thirty subjects with mild AP and 29 healthy controls were enrolled into the study. The levels of TAS, TOS and IMA, C- reactive protein (CRP), high sensitivity CRP (hs-CRP) and fibrino- gen were measured in both groups. Results : TAS levels were significantly lower (p = 0.037), while IMA levels were significantly higher (p < 0.001) in patients, com- pared to controls. TOS levels were similar between two groups. Fibrinogen, CRP and hs-CRP levels were significantly higher in patients than those of controls (p < 0.001 for all parameters). IMA levels were positively correlated with amylase and lipase levels (r = 0.448, p = 0.001 and r = 0.469, p < 0.001, respectively). There was a negative correlation between TAS levels, and amylase and lipase levels (r = -0.277, p = 0.035 and r = -0.278, p = 0.034, respec- tively).