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Preemptive liver transplantation for primary hyperoxaluria type 1

Journal Volume 68 - 2005
Issue Fasc.4 - Symposium
Author(s) P. Cochat, A. Liutkus
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Centre de Référence des Maladies Rénales Héréditaires et Inserm U499, Hôpital Edouard-Herriot & Université Claude-Bernard, Lyon, France

Hyperoxaluria may be either a secondary or a primary disease. Secondary hyperoxaluria is due to oxalate poisoning, i.e., accidental intoxication with precursors such as ethylene glycol, absorptive hyperoxaluria of bowel disease. Two distinct inherited enzyme defects have been related to type 1 and type 2 primary hyperoxalurias (PH), i.e., alanine : glyoxylate aminotransferase (AGT) and glyoxylate reductase/hydroxypyruvate reductase, respectively ; in addition non-PH1 non-PH2 patients have been reported

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